New research reveals that individuals who come off popular slimming jabs like Wegovy and Mounjaro tend to recover reduced body mass much more quickly than those who stop conventional diet and exercise programs.
Findings released in a prominent health publication points out that while obese individuals frequently drop substantial amounts of their total mass while on the medication, the mass returns at an average rate of 0.8 kg per month once they quit.
"Individuals purchasing these treatments need to be informed of the danger of fast rebound weight gain when the treatment ends," stated researcher Dr. Susan Jebb.
This pace of regain means a reversion to starting weight in about one and a half years.
Weighing Treatments
The study, which reviewed dozens of trials involving thousands of participants, compared the outcomes of these new drugs with conventional dieting.
The team emphasize that individuals who lose weight through dieting usually experience a less rapid weight regain—around 0.1 kg a month—once they finish.
Explaining the Rapid Rebound
Nutrition scientists propose the mechanism of the injections is key to understanding the amplified regain.
GLP-1 drugs imitate a natural hormone called glucagon-like peptide-1, which moderates feelings of fullness.
"Long-term administration of GLP-1 levels far above than normal could lead to the system to generate a reduced amount of its own natural hormone, and may also diminish sensitivity to its actions," noted Dr. Adam Collins, a nutrition expert.
"Stopping of this medication means appetite is no longer kept in check, making binge eating a significant risk."
A Lifelong Disease?
The NHS suggest the jabs for people with obesity-related medical conditions, alongside recommended lifestyle changes.
Many experts contend that, considering the likelihood of relapse, the therapy is often life-long.
This view is supported by pharmaceutical companies, who state that the findings "highlight the persistent nature of obesity," similar to managing diseases like diabetes.
User Experiences
Individuals who have discontinued the medication explain a intense resurgence of cravings.
"It felt as if a trigger that goes on and you become extremely hungry," recalled an individual.
This challenge is compounded if patients have not developed sustainable lifestyle or habit modifications during therapy.
Widespread Adoption
Survey data show that a significant number of adults in the UK have tried weight-loss jabs in the past year, with desire continuing to grow.
- Use is greater among women compared to men.
- The 40s and 50s age group shows the greatest usage rates.
- A large proportion obtain the medications through private prescriptions rather than the NHS.
Ultimately, experts caution that while GLP-1 drugs are powerful agents for shedding pounds, they are not a magic solution and lasting health benefits relies on combined lifestyle management.
